Key result
Multidisciplinary team care and validated risk stratification optimize management of high-risk pregnant patients with HCM.
Why the study?
Hypertrophic cardiomyopathy in pregnancy presents unique hemodynamic and arrhythmic challenges despite generally low maternal mortality, requiring synthesized guidance across the reproductive continuum.
Supports multidisciplinary teams and CARPREG II/mWHO stratification in HCM pregnancy; extends prior frameworks but leaves prospective validation open.
Hypertrophic cardiomyopathy (HCM) in pregnancy presents unique hemodynamic and arrhythmic challenges despite generally low maternal mortality. This JACC State-of-the-Art Review synthesizes current evidence on preconception risk stratification, genetic counseling, antepartum surveillance, arrhythmia management, and delivery and postpartum care. Key considerations include assessing left ventricular outflow tract obstruction, systolic function, and arrhythmia burden and applying CARPREG II (Cardiac Disease in Pregnancy Study II)/modified World Health Organization classifications to guide monitoring intensity. Pregnancy is typically well tolerated in low-risk women, whereas severe obstruction or systolic dysfunction confers high maternal-fetal risk. Multidisciplinary pregnancy heart team management remains essential to optimize outcomes and support informed decision making across the reproductive continuum.
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Abdelfattah et al. (2026) conducted a review in Hypertrophic cardiomyopathy in pregnancy. Multidisciplinary pregnancy heart team management and risk stratification was evaluated. Multidisciplinary pregnancy heart team management and CARPREG II/mWHO risk stratification guide care in pregnant women with HCM, where severe obstruction or systolic dysfunction confers high risk.
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