Does clopidogrel plus aspirin improve safety and tolerability compared to ticlopidine plus aspirin in patients after coronary stenting?
Clopidogrel plus aspirin provides superior safety and tolerability compared to ticlopidine plus aspirin after coronary stenting, while maintaining comparable efficacy for preventing cardiac events.
The safety/tolerability of clopidogrel (plus aspirin) is superior to that of ticlopidine (plus aspirin) (P=0.005). The 300-mg loading dose was well tolerated, notably with no increased risk of bleeding. Secondary end point data are consistent with the hypothesis that clopidogrel and ticlopidine have comparable efficacy with regard to cardiac events after successful stenting.
Bertrand et al. (Tue,) studied this question.
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