What question did this study set out to answer?

To assess the mortality risk in patients with coronary artery disease by combining BMI and measures of central obesity.

April 25, 2026Journal of the American College of Cardiology

Combining Body Mass Index With Measures of Central Obesity in the Assessment of Mortality in Subjects With Coronary Disease

Q: What are the key findings of this study?

Normal weight central obesity in patients with coronary artery disease was associated with higher mortality than obesity with central adiposity (HR 1.27; 95% CI 1.18-1.39; P<0.0001).

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Coronary artery disease (CAD) (n=15547). Intervention: Normal weight central obesity vs. Other combinations of BMI and waist circumference. Primary outcome: Mortality (HR 1.27, 95% CI 1.18 to 1.39, p=< 0.0001).

View Full Paper

Ask AI

Bookmark

Key result

Normal-weight central obesity in CAD is associated with ~27% higher mortality than obesity with central adiposity.

HR 1.27
95% CI 1.18 to 1.39
P<0.0001
n=15,547

Why the study?

In CAD patients, mortality varies inversely with BMI but directly with central obesity, raising questions about mortality risk when combining both measures.

Population

15,547 participants with CAD from 5 studies across 3 continents

Comparison

Different patterns of adiposity combining BMI with measures of central obesity

Design

Pooled cohort analysis

Follow-up

Median 2.4 years

Authors

TCThais CoutinhoMayo Clinic KGKashish GoelInterventional Cardiology DSDaniel Corrêa de Sá

Discussion

Member takes

Implication

BMI may underestimate mortality risk in CAD with central obesity; leaves open whether visceral fat reduction improves survival.

Key Points

To assess the mortality risk in patients with coronary artery disease by combining BMI and measures of central obesity.
Included 15,547 individuals with coronary artery disease from 5 studies across 3 continents.
Utilized multivariate stratified Cox-proportional hazard models to evaluate mortality risk.
Adjusted for potential confounders.
Mean age of participants was 66 years, with 5,507 deaths during a median follow-up of 2.4 years.
Patients with normal weight central obesity exhibited the highest mortality risk (HR: 1.10, 95% CI: 1.05 to 1.17).
Higher mortality observed in individuals with normal BMI and increased waist circumference compared to others, with significant p-values (< 0.0001).

Study Design

Type

Cohort (n=15,547)

Multicenter

Yes

PICO

Population

Coronary artery disease (CAD) (n=15,547)

Intervention / Comparator

Normal weight central obesity vs Other combinations of BMI and waist circumference

Primary Outcome

Mortality — HR 1.27 (1.18 to 1.39), p=< 0.0001

Main Result

Effect estimate: HR 1.27 (95% CI 1.18 to 1.39)

p-value: p=< 0.0001

Cite This Study

Coutinho et al. (2013) conducted a cohort in Coronary artery disease (CAD) (n=15,547). Normal weight central obesity vs. Other combinations of BMI and waist circumference was evaluated on Mortality (HR 1.27, 95% CI 1.18 to 1.39, p=< 0.0001). Normal weight central obesity in patients with coronary artery disease was associated with higher mortality than obesity with central adiposity (HR 1.27; 95% CI 1.18-1.39; P<0.0001).

synapsesocial.com/papers/69ecdb67eb2c6328dba62cdf https://doi.org/10.1016/j.jacc.2012.10.035

Topics

Coronary artery disease

View Full Paper

Ask AI

Bookmark

Combining Body Mass Index With Measures of Central Obesity in the Assessment of Mortality in Subjects With Coronary Disease

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Topics

Combining Body Mass Index With Measures of Central Obesity in the Assessment of Mortality in Subjects With Coronary Disease

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider