Key result
Very high CAC linked to substantially higher risk of CVD events, non-CVD outcomes, and mortality.
Why the study?
Are individuals with very high CAC (≥1000) at higher risk for CVD events, non-CVD outcomes, and mortality compared to those with lower CAC?
Observational
Are individuals with very high CAC (≥1000) at higher risk for CVD events, non-CVD outcomes, and mortality compared to those with lower CAC?
Patients with CAC ≥1000 have MACE rates comparable to secondary prevention populations, suggesting they may benefit from similarly aggressive preventive pharmacotherapy.
Individuals with very high CAC (≥1000) are a unique population at substantially higher risk for CVD events, non-CVD outcomes, and mortality than those with lower CAC, with 3-point major adverse cardiovascular event rates similar to those of a stable treated secondary prevention population. Future guidelines should consider a less distinct stratification algorithm between primary and secondary prevention patients in guiding aggressive preventive pharmacotherapy.
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Peng et al. (2021) conducted an observational in Very high coronary artery calcium. Very high coronary artery calcium (≥1000) vs. Lower coronary artery calcium was evaluated on Cardiovascular disease events, non-cardiovascular disease outcomes, and mortality. Very high coronary artery calcium (≥1000) is associated with a substantially higher risk for CVD events, non-CVD outcomes, and mortality compared to lower CAC.
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