Key result
Zero CAC score predicts very low CVD mortality of ~0.3 per 1000 person-years across sexes.
Why the study?
The age- and sex-specific relationship of coronary artery calcium with cardiovascular and cancer mortality was unknown.
Does the age- and sex-specific coronary artery calcium (CAC) score predict the relative risk of cardiovascular versus cancer mortality in asymptomatic patients without known CVD?
Population
59,502 asymptomatic patients aged 40 to 75 years without known CVD
Comparison
Age- and sex-specific CAC scores related to CVD versus cancer mortality risk
Design
Cohort study
Follow-up
Mean 12±3 years
Authors
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May refine sex-specific competing mortality estimates with CAC; leaves open whether thresholds alter clinical decisions.
Cohort (n=59,502)
Does the age- and sex-specific coronary artery calcium (CAC) score predict the relative risk of cardiovascular versus cancer mortality in asymptomatic patients without known CVD?
The age- and sex-specific relationship of CAC with CVD and cancer mortality differs significantly between men and women, allowing for more precise risk prediction.
Dzaye et al. (2020) conducted a cohort in Asymptomatic without known CVD (n=59,502). Coronary artery calcium (CAC) score vs. CAC=0 was evaluated on CVD and cancer mortality. Coronary artery calcium (CAC) scores had differing age- and sex-specific relationships with mortality, with CAC=0 predicting very low CVD mortality rates (0.3 per 1000 person-years for both sexes).
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