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The study aims to understand how acute high-intensity exercise impacts gut microbiota composition and energy metabolism in different mouse strains.

Acute high-intensity exercise alters gut microbiota composition and energy metabolism in different strains of mice

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The study aims to understand how acute high-intensity exercise impacts gut microbiota composition and energy metabolism in different mouse strains.
Age-matched male BALB/c and C57BL/6 mice underwent a 30-min high-intensity treadmill run.
Colonic content samples were collected at 0, 30, and 60 min post-exercise for 16S rRNA gene sequencing.
Alpha and beta diversity metrics were analyzed to assess microbial changes over time.
Significant increase in the Bacteroidetes/Firmicutes ratio post-exercise in C57BL/6 mice (p < 0.01).
C57BL/6 mice showed greater diversity improvements at 30 and 60 min post-exercise (p < 0.001).
BALB/c mice had upregulated energy metabolism enzymes but compromised immune regulation compared to C57BL/6 mice.

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Randomized trial investigates gut microbiota changes after high-intensity exercise in mice, indicating gut health implications.

Gao et al. (2026) studied this question.

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