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April 26, 2026British Journal of Biomedical ScienceOpen Access

Clinical Utility of SARS-CoV-2 Antibody Titers in the Management of Patients With Long COVID Infected With the Omicron Variant

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Authors

MKMarina KawaguchiYSYasue SakuradaKTKazuki Tokumasu

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Overview

Retrospective observational study finds antibody levels indicate clinical features of Long COVID.

Key Points

  • To investigate the correlation between S- and N-antibody titers and clinical features of Long COVID in patients infected with the Omicron variant.
  • Retrospective observational study of 275 patients with Omicron-related Long COVID.
  • Included analysis of S- and N-antibody levels in relation to vaccination status and disease severity.
  • Evaluated correlations between antibody titers and quality of life, cognitive symptoms, and immunological markers.
  • Vaccinated patients had median S-antibody titers of 20,963 U/mL compared to 24 U/mL in unvaccinated patients.
  • N-antibody titers were associated with disease severity, showing a decline of 0.34% per day from infection to clinic visit.
  • Lower S-antibody titers correlated with memory impairment and reduced quality of life in patients.

Cite This Study

Kawaguchi et al. (2026) studied this question.

synapsesocial.com/papers/69edaafc4a46254e215b336bhttps://doi.org/10.3389/bjbs.2026.16255
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