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April 26, 2026Frontiers in Cellular and Infection MicrobiologyOpen Access

The therapeutic potential of epimedium and its bioactive flavonoids in hepatitis and cirrhosis: an integrative review

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Authors

JZJianyi ZhangGuangzhou University of Chinese MedicineWJWeichi JiangGuangzhou University of Chinese MedicineHFHuigang FengPanyu District Central Hospital

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Implication

Integrative review examines Epimedium's effects on hepatitis and cirrhosis, highlighting important therapeutic insights.

Key Points

  • This review aims to evaluate the therapeutic potential of Epimedium and its bioactive flavonoids in treating hepatitis and cirrhosis.
  • Conducted a review of 33 high-impact studies published until March 2026.
  • Analyzed preclinical evidence from toxin-induced and metabolic liver injury models.
  • Critically evaluated mechanisms of action, including HIF-1α and TGF-β/Smad signaling pathways.
  • Icaritin demonstrated consistent anti-fibrotic activity through dual inhibition of key signaling pathways.
  • Immunomodulation was observed with CD8+ T-cell function enhanced by 2.8-fold and reduction of myeloid-derived suppressor cells by 43%.
  • Current evidence is limited, lacking phase III trials targeting fibrosis and cirrhosis endpoints.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69edaafc4a46254e215b3403https://doi.org/10.3389/fcimb.2026.1799319
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrating metabolomics and bioinformatics to reveal the mechanism of Epimedium‐induced liver injury2024 · 5 citations
  2. 2Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation2023 · 25 citations
  3. 3Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation2024 · 38 citations
  4. 4Icariin Metabolism by Human Intestinal Microflora2016 · 89 citations