Comprehensive In-silico Profiling of CYP2C19 Genetic Variants in the Egyptian Population: Structural Bioenergetics and Clinical Implications for Precision Pharmacotherapy

Key Result

Computational analysis of CYP2C19 variants (*2 and *17) in the Egyptian population predicted functional impacts on Clopidogrel metabolism, supporting genotype-guided therapy.

Key Points

• This research aims to analyze CYP2C19 genetic variants and their effects on drug metabolism in the Egyptian population.
• Conducted a computational analysis of CYP2C19 variants using genomic data.
• Integrated structural bioenergetics to assess functional implications.
• Focused on key variants such as CYP2C192 and CYP2C1917.
• Identified significant functional consequences of CYP2C19 variants on Clopidogrel metabolism.
• Supported the need for implementing genotype-guided therapy in clinical practices in Egypt.