Key result
Computational analysis links CYP2C19 variants to altered clopidogrel metabolism in Egyptians, supporting genotype-guided therapy.
Hypothesis-generating for CYP2C19-guided clopidogrel therapy in Egyptians; leaves open need for prospective clinical validation.
This research presents a computational analysis of CYP2C19 genetic variants in the Egyptian population and their impact on drug metabolism, particularly Clopidogrel. The study integrates genomic data and structural bioenergetics to predict functional consequences of key variants such as CYP2C192 and CYP2C1917. The findings support the need for genotype-guided therapy in Egyptian clinical practice.
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Ahmed Khalil (2026) studied CYP2C19 genetic variants affecting drug metabolism. Computational analysis of CYP2C19 variants (*2 and *17) in the Egyptian population predicted functional impacts on Clopidogrel metabolism, supporting genotype-guided therapy.
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