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Investigate the effects of mindfulness meditation on cognitive flexibility and its neurophysiological basis in adolescents with OCD.

April 26, 2026Neuroimage ReportsOpen Access

App-based mindfulness meditation training enhances cognitive flexibility and modulates ACC and medial frontal gyrus activation during task switching in adolescent OCD

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Randomized trial demonstrates improved cognitive flexibility in adolescents with OCD, suggesting mindfulness as a valuable intervention.

Investigate the effects of mindfulness meditation on cognitive flexibility and its neurophysiological basis in adolescents with OCD.
Randomized, interviewer-blind design
53 adolescents with OCD engaged in mindfulness training or audiobook control group
Cognitive flexibility assessed via task-switching paradigm with concurrent EEG data collection
Mindfulness group showed reduced switch costs compared to control group, indicating improved cognitive flexibility
Group-specific decoding effects in EEG data observed during stimulus-response selection
Enhanced activation in medial frontal gyrus and anterior cingulate cortex for mindfulness participants during task switching

Rempel et al. (2026) studied this question.

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