What question did this study set out to answer?

This study aims to assess salivary cortisone and copeptin-derived ratios as biomarkers for glucocorticoid replacement adequacy in primary adrenal insufficiency.

April 26, 2026Journal of Endocrinological InvestigationOpen Access

Novel biomarkers to guide glucocorticoid replacement in primary adrenal insufficiency: a proof-of-concept study using copeptin-derived ratios

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Authors

CBChiara BimaAzienda Ospedaliera Citta' della Salute e della Scienza di Torino LCLorenzo CampioniAzienda Ospedaliera Citta' della Salute e della Scienza di Torino ABAlessandro Maria BertonDepartment of Medical Sciences

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Implication

Cross-sectional proof-of-concept study evaluates biomarkers for glucocorticoid replacement in primary adrenal insufficiency, suggesting potential for improved therapy.

Key Points

This study aims to assess salivary cortisone and copeptin-derived ratios as biomarkers for glucocorticoid replacement adequacy in primary adrenal insufficiency.
Cross-sectional case–control study over 12 months.
Involves 19 adults with primary adrenal insufficiency and 43 healthy controls.
Saliva samples collected for cortisol and cortisone analysis; copeptin and plasma ACTH levels measured.
31.6% of patients showed glucocorticoid excess at baseline, increasing to 36.8% at follow-up.
Group A had higher HbA1c (46.5 vs. 34.0 mmol/mol, p < 0.05) and blood pressure, indicating poorer control.
ACTH/copeptin ratios were significantly lower in Group A, correlating with salivary cortisone AUC (r = − 0.59, p < 0.01).

Cite This Study

Bima et al. (2026) studied this question.

synapsesocial.com/papers/69edab424a46254e215b3582 https://doi.org/10.1007/s40618-026-02874-8

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Implication

Cross-sectional proof-of-concept study evaluates biomarkers for glucocorticoid replacement in primary adrenal insufficiency, suggesting potential for improved therapy.

Novel biomarkers to guide glucocorticoid replacement in primary adrenal insufficiency: a proof-of-concept study using copeptin-derived ratios

Discussion

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Implication

Key Points

Cite This Study

Novel biomarkers to guide glucocorticoid replacement in primary adrenal insufficiency: a proof-of-concept study using copeptin-derived ratios

Discussion

Member takes

Implication

Key Points

Cite This Study

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