B-98 | Impact of Protein Malnutrition on Outcomes in Hospitalized Patients with Pulmonary arterial Hypertension: A Nationwide Analysis

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Key Points

This study aims to assess the effects of protein malnutrition on outcomes in hospitalized patients with pulmonary arterial hypertension (PAH).
Conducted a systematic review of trials focusing on PADN in Group 2 CpcPH with PVR >3.0 WU.
Amalgamated data from the PADN-5 trial including 98 randomized patients across 6-month and 3-year cohorts.
Measured outcomes included 6-minute walk distance (6MWD), pulmonary vascular resistance (PVR), and clinical condition worsening.
At 6 months, patients receiving PADN showed an improvement of +83m in 6MWD compared to sildenafil controls (p<0.01).
In the HFpEF subgroup, PADN resulted in a 55% decrease in NT-proBNP versus 10% in controls over 3 years.
PADN significantly reduced clinical worsening (death/rehospitalization) by 3 years (HR 0.15; 95% CI: 0.04-0.58; p=0.006).

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Evaluates protein malnutrition's impact on pulmonary arterial hypertension outcomes, suggesting potential effects on clinical progression.

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Emmanuel Olumuyide (2026) studied this question.

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