Meta-Analysis of Pulmonary Artery Denervation for Treatment of Pulmonary Hypertension

Fig. 1. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (or PRISMA) flow chart of study selection. EMBASE=Excerpta Medica dataBASE.

Fig. 2. Risk of bias graph: the green color indicates low risk of bias, and the yellow indicates unclear risk of bias. Newcastle-Ottawa Scale (NOS): a=representativeness of exposed cohort; b=representativeness of non-exposed cohort; c=ascertainment of exposure; d=demonstration that outcome of interest was not present at the start of study; e=comparability; f=assessment of outcome; g=duration of follow-up; h=adequacy of follow-up

Fig. 3. Forest plot for comparison of hemodynamic parameters between post pulmonary artery denervation (PADN) period and pre-PADN period: A) mean pulmonary artery pressure (mmHg); B) pulmonary vascular resistance (Wood unit). CI=confidence interval; SD=standard deviation

Fig. 4. Forest plot for comparison of hemodynamic parameters between post pulmonary artery denervation (PADN) period and pre-PADN period: A) cardiac output (L/min); B) right ventricular Tei index. CI=confidence interval; SD=standard deviation

Fig. 5. Forest plot for comparison of quality of life between post pulmonary artery denervation (PADN) period and pre-PADN period: A) 6-minute walk distance (meter); B) New York Heart Association cardiac function grading. CI=confidence interval; SD=standard deviation

Fig. 6. Subgroup analysis: A) mean pulmonary artery pressure (mmHg); B) pulmonary vascular resistance (Wood unit); C) cardiac output (L/min). CI=confidence interval; PADN=pulmonary artery denervation; SD=standard deviation

Fig. 7. Funnel plots: A) funnel plot of mean pulmonary artery pressure (mmHg); B) funnel plot of pulmonary vascular resistance (Wood unit); C) funnel plot of cardiac output (L/min); D) funnel plot of right ventricular Tei index; E) funnel plot of 6-minute walk distance (meter); F) funnel plot of New York Heart Association cardiac function grading. MD=mean differences; RR=risk ratios; SE=standard error