D-41 | Trends and Outcomes in Cardiac Arrest with Diabetes Mellitus related Mortality Among Adults (1999-2024): A Nationwide Analysis

Background: Cardiac arrest (CA) is a leading cause of death in the U.S., and individuals with diabetes mellitus (DM) face heightened risks due to common comorbidities like obesity and hypertension.This study analyzes trends in CA mortality among U.S. adults with DM from 1999 to 2024 using data from the CDC WONDER database.Methods: Data were extracted from the CDC WONDER system for adults aged 25+ years with both CA and DM listed as causes of death.Annual crude and age-adjusted mortality rates (AAMR) were calculated, and Joinpoint regression identified temporal trend changes with annual percent changes (APC) and average annual percent changes (AAPC).Results: From 1999-2024, there were 1,146,259 CA-related deaths among DM patients.The overall AAMR decreased from 21.3 in 1999 to 18.3 in 2024 (AAPC: -0.69, 95% CI: -0.99 to -0.46).The AAMR for men was 23.9 and for women was 16.1.Non-Hispanic Black individuals had the highest AAMR (37.1), followed by Hispanics (33.2).The Western U.S. had the highest burden (29.0).Urban areas had a slightly higher AAMR (19.4) than rural areas (18.7).Conclusions: CA mortality among diabetic adults decreased until 2018 but surged in urban areas, highlighting vulnerabilities, particularly among men, non-Hispanic Black, and Hispanic populations, as well as those in high-burden regions.Addressing healthcare disparities and improving emergency response systems remain crucial.