Speed of intravenous fluid on glycocalyx integrity and central blood volume in a porcine septic shock model

Key Points

• To evaluate how the speed of intravenous fluid administration affects glycocalyx integrity and central blood volume in a porcine model of septic shock.
• Administered intravenous fluids (IVF) at different speeds: 5 min and 20 min.
• Measured glycocalyx degradation and vascular shear stress as outcomes.
• Analyzed central blood volume changes in both groups.
• No significant difference in glycocalyx degradation between the fast (5 min) and slow (20 min) IVF groups.
• No significant difference in vascular shear stress between the two groups.
• Observed a trend towards increased central blood volumes in the slow IVF group compared to the fast IVF group.