Key result
Poor sleep linked to higher CKM syndrome risk and severity, mediated by obesity and metabolic factors.
Observational
Mediation analysis finds inflammation mediates sleep effects on CKM syndrome, suggesting risk reduction strategies.
Poor sleep patterns are robustly associated with an increased risk and severity of CKM syndrome. While systemic inflammation was correlated with both sleep disturbances and CKM, its role as an independent mediator was largely explained by shared variance with obesity and metabolic factors. These findings underscore sleep health as a potential target for multimodal risk reduction within the CKM framework, though causality needs confirmation in longitudinal studies.
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Hu et al. (2026) conducted an observational in Cardiovascular-Kidney-Metabolic (CKM) syndrome. Poor sleep patterns was evaluated on Risk and severity of CKM syndrome. Poor sleep patterns were robustly associated with increased risk and severity of CKM syndrome, with inflammation's mediating role largely explained by obesity and metabolic factors.
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