Key result
Biochemically silent paraganglioma triggers intraoperative hypertensive crisis despite normal catecholamines.
Why the study?
Paragangliomas can appear biochemically silent yet act functionally, presenting a risk of intraoperative hypertensive crisis despite normal preoperative catecholamine screening.
Case Report (n=1)
Biochemically silent paragangliomas can still precipitate life-threatening intraoperative hypertensive crises, necessitating perioperative preparedness.
High suspicion and multidisciplinary preparedness remain critical for paraganglioma surgery; leaves open prevalence and mechanisms of biochemically silent functional tumors.
Paragangliomas may appear biochemically silent, yet still behave as functional tumors with severe intraoperative consequences. Normal preoperative catecholamine screening does not exclude the risk of hypertensive crisis during surgery. Thorough biochemical evaluation, high clinical suspicion, and perioperative preparedness with multidisciplinary planning are essential to prevent life‐threatening complications.
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Basit et al. (2026) conducted a case report in Biochemically silent aortocaval paraganglioma (n=1). A biochemically silent aortocaval paraganglioma in a 19-year-old female caused a severe intraoperative hypertensive crisis despite normal preoperative catecholamine screening.
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