Stroke Etiologies With Intravenous Thrombolysis before Thrombectomy and Functional Outcomes in Anterior Circulation Large Vessel Occlusion

Changwei Guo; Fabiano Cavalcante; S J Yang; Kentaro Suzuki; Kilian Treurniet; Johannes Kaesmacher; Manon Kappelhof; Roman Rohner; Jiaxing Song; Pengfei Yang; Xiaolei Shi; Gaoming Li; Xu Xu; J X; Lilan Wang; J W Liu; Li Li; Pengfei Xing; Bernard Yan; Chang Liu; Lei Zhang; Yongwei Zhang; Kendal Redmond; Yi Zhou; Peter Mitchell; Mirjam R. Heldner; Hester Lingsma; J Gralla; Urs Fischer; Yvo Roos; Fengli Li; Raul G. Nogueira; Thanh N. Nguyen; Jeffrey Saver; Charles Majoie; Kazumi Kimura; Wenjie Zi; Qingwu Yang; for the IRIS Investigators

doi:10.1002/ana.78225

Key Points

To assess the impact of stroke etiologies on the efficacy and safety of intravenous thrombolysis (IVT) prior to thrombectomy (EVT) in patients with large vessel occlusion (LVO).
Evaluated patients with LVO presenting to EVT-capable centers
Analyzed outcomes of IVT before EVT
Investigated specific stroke etiologies and their effects on outcomes.
No significant modification in efficacy or safety of IVT based on stroke etiologies.
Isolated benefit noted in other/undetermined subgroup, pending confirmation.

Implication

Evaluates stroke etiologies' impact on outcomes in large vessel occlusion, suggesting IV thrombolysis before thrombectomy is safe and effective.

Abstract

Among patients with LVO presenting directly to EVT-capable centers, stroke etiologies do not modify the overall efficacy or safety of IVT before EVT. The isolated benefit observed in the other/undetermined subgroup requires confirmation. ANN NEUROL 2026 ANN NEUROL 2026.

Discussion

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Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69edac2e4a46254e215b3e68 https://doi.org/10.1002/ana.78225

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Stroke Etiologies With Intravenous Thrombolysis before Thrombectomy and Functional Outcomes in Anterior Circulation Large Vessel Occlusion

Key Points

Implication

Abstract

Discussion

Cite This Study

Stroke Etiologies With Intravenous Thrombolysis before Thrombectomy and Functional Outcomes in Anterior Circulation Large Vessel Occlusion

Key Points

Implication

Abstract

Discussion

Cite This Study

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