Shows EphA2 signaling enhances antimicrobial defense in alveolar macrophages, suggesting a novel inflammation modulation strategy.
EphA2 signaling plays a critical role in AM-mediated host defense against Pneumocystis by promoting inflammatory responses necessary for organism control. However, this pathway also contributes to lung inflammation. Targeting EphA2 may represent a novel strategy to modulate inflammation during severe PCP while preserving antimicrobial defense.
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Kottom et al. (2026) studied this question.
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