What question did this study set out to answer?

Examine the persistence of high-risk HPV (hrHPV) in Malawian women after thermal ablation, with regard to HIV status.

April 26, 2026Women s HealthOpen Access

Persistent human papillomavirus after thermal ablation in Malawian women with and without HIV: Implications for risk-based cervical cancer prevention in low- and middle-income countries

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Examine the persistence of high-risk HPV (hrHPV) in Malawian women after thermal ablation, with regard to HIV status.
Analyzed hrHPV persistence 12 months after thermal ablation in women with and without HIV.
Assessed prevalence of hrHPV genotypes, focusing on non-16/18/45 types.
Conducted in Malawi with emphasis on low-resource settings.
Over one-third of women (exact percentage not specified) had persistent hrHPV at 12 months after treatment.
Higher rates of persistence were observed in women living with HIV (WLWH) for non-16/18/45 genotypes.
Findings support the need for enhanced follow-up and adjunct therapies to improve clearance.

Implication

Randomized trial shows persistent HPV 12 months post-thermal ablation in Malawian women, suggesting enhanced follow-up is needed for cancer prevention.

Abstract

Over one-third of women had persistent hrHPV 12 months after TA, with higher rates among WLWH, primarily for non-16/18/45 genotypes. Findings highlight the need for enhanced follow-up and adjunct therapies to improve post-treatment clearance and advance cervical cancer prevention in low-resource settings.

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Cite This Study

Gingles et al. (2026) studied this question.

synapsesocial.com/papers/69edac9b4a46254e215b45c3 https://doi.org/10.1177/17455057261428547

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Implication

Randomized trial shows persistent HPV 12 months post-thermal ablation in Malawian women, suggesting enhanced follow-up is needed for cancer prevention.

Persistent human papillomavirus after thermal ablation in Malawian women with and without HIV: Implications for risk-based cervical cancer prevention in low- and middle-income countries

Key Points

Implication

Abstract

Discussion

Cite This Study

Persistent human papillomavirus after thermal ablation in Malawian women with and without HIV: Implications for risk-based cervical cancer prevention in low- and middle-income countries

Key Points

Implication

Abstract

Discussion

Cite This Study

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