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April 24, 2026JAMA

Could a Common Antidepressant Help Treat Methamphetamine Use Disorder?

Samantha Anderer

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Key Points

The aim is to explore the effectiveness of mirtazapine in treating methamphetamine use disorder.
Discusses potential applications of mirtazapine in a clinical context.
Analyzes current literature and hypotheses surrounding antidepressants and substance use treatment.
Suggests mirtazapine may offer therapeutic benefits for individuals with methamphetamine use disorder.

Implication

Medical News article discusses mirtazapine's potential to treat methamphetamine use disorder, suggesting new therapeutic avenues.

Abstract

This Medical News article discusses the potential for the antidepressant mirtazapine to treat methamphetamine use disorder.

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Cite This Study

Samantha Anderer (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b46c5 https://doi.org/10.1001/jama.2026.5755

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Study: Mirtazapine found effective in reducing methamphetamine useOriginal Research · 2026
2Mirtazapine reduces methamphetamine use in Phase 3 trialLate-Phase Clinical Trial · 2026
3Mirtazapine for Methamphetamine Use Disorder: A Randomized Double-blind Placebo-controlled Trial on Craving, Mood, and AbstinenceRCT · 2026
4A phase 3 randomised double-blind placebo-controlled trial of mirtazapine as a pharmacotherapy for methamphetamine use disorder: a study protocol for the Tina Trial2024 · 8 citations
5Safety of Intravenous Methamphetamine in Patients Taking MirtazapineBlinded Clinical Trial · 2026