PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 26, 2026Angewandte Chemie0 citations

Divergent Cysteine Modification Using Indole Isocyanide Photochemistry

Catalyst‐Free, Divergent Cysteine Modification via Indole Isocyanide Photochemistry

View Full Paper
Ask AI
Bookmark
Share

Authors

HWHan WeiGZGuanghe ZhuRZRuiying Zhu

Discussion

Loading...

Member takes

Overview

Randomized trial shows effective cysteine modification in biochemical applications, highlighting therapeutic potential.

Key Points

  • This research aims to develop a catalyst-free method for selective cysteine modifications using photochemical techniques.
  • Utilized visible-light photochemistry with indole isocyanides for cysteine modification.
  • Implemented both solution-phase and solid-phase reaction systems for flexibility.
  • Conducted chemical proteomics profiling to analyze interactions with target proteins.
  • Achieved broad utility for site-specific modification of peptides and proteins.
  • Identified a novel allosteric inhibition strategy within the phosphatase PPP5C.
  • Generated diverse indole-fused and indole-spiro aza-cycles at cysteine residues.

Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b4722https://doi.org/10.1002/ange.202524506
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Visible‐Light‐Induced Trifluoromethylation of Isonitrile‐Substituted Indole Derivatives: Access to 1‐(Trifluoromethyl)‐4,9‐dihydro‐3H‐pyrido[3,4‐b]indole and β‐Carboline Derivatives2018 · 26 citations
  2. 2Site‐Selective Installation of Nϵ‐Modified Sidechains into Peptide and Protein Scaffolds via Visible‐Light‐Mediated Desulfurative C–C Bond Formation2021 · 13 citations
  3. 3Visible Light-Induced Trifluoromethylation and Perfluoroalkylation of Cysteine Residues in Batch and Continuous Flow2016 · 68 citations
  4. 4Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis2017 · 170 citations
  5. 5Analysis and Visualization of Quantitative Proteomics Data Using FragPipe-Analyst2024 · 126 citations