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April 26, 2026Veterinary Medicine and ScienceOpen Access

Effects of Topical Steroids and Non‐Steroidal Anti‐Inflammatory Drugs on Gastrointestinal Bleeding in Rats

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Authors

HÇHarun ÇınarLYLatif Emrah YanmazÖÖÖzlem Özmen

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Overview

Randomized trial investigates gastrointestinal effects of topical steroids and NSAIDs in rats, suggesting no significant alterations.

Key Points

  • This study aimed to explore the systemic gastrointestinal effects of topical steroids and NSAIDs in rats.
  • 56 adult male Wistar rats were assigned to seven treatment groups (n=8) with various topical agents.
  • GI bleeding assessed through faecal occult blood tests, endoscopy, and histopathological analysis.
  • Interventions included saline, prednisolone acetate, dexamethasone phosphate, loteprednol etabonate, ketorolac tromethamine, nepafenac, and diclofenac sodium for 1 week.
  • Positive faecal occult blood results in prednisolone acetate (37.5%), dexamethasone phosphate (25%), diclofenac (12.5%), and loteprednol (12.5%) groups.
  • No positive results in ketorolac tromethamine, nepafenac, or saline groups (0%).
  • No significant differences between groups or within-group results post-treatment (p>0.05).

Cite This Study

Çınar et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b47b5https://doi.org/10.1002/vms3.70962
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic absorption and gastrointestinal adverse effects from topical ketorolac and diclofenac ophthalmic solutions in healthy dogs2024 · 2 citations
  2. 2Intraocular Pressure During Short-Term Topical or Systemic Corticosteroid Treatment2026
  3. 3Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs): Ocular Pharmacology, Pharmaceutical Innovations, and Drug Delivery Perspectives2026
  4. 4COMPARISON OF THE EFFECTS OF EIGHT DIFFERENT TOPICAL NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ON REDUCING INTRAVITREAL INJECTION–INDUCED PAIN2024
  5. 5Comparative Histopathological Effects of Several Non-Selective NSAIDs on Gastric Mucosa in Wistar Rats2025