Key result
Preoperative 10% dextrose fails to reduce intraoperative remifentanil requirements vs control during controlled hypotension.
Why the study?
The study was conducted to evaluate the effect of preoperative carbohydrate-rich fluid consumption on intraoperative narcotic analgesic requirements in surgeries requiring controlled hypotension.
Does preoperative oral 10% Dextrose solution reduce intraoperative Remifentanil requirement in patients undergoing surgery requiring controlled hypotension?
RCT (n=40)
No
Does preoperative oral 10% Dextrose solution reduce intraoperative Remifentanil requirement in patients undergoing surgery requiring controlled hypotension?
Preoperative oral carbohydrate loading does not significantly reduce intraoperative narcotic analgesic requirements during surgeries requiring controlled hypotension.
Answers are grounded in this paper and cite their sources.
No role for preoperative carbohydrate loading to spare opioids; challenges its hypothesized benefit in controlled hypotension.
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Söğüt et al. (2026) conducted an RCT in Surgeries requiring controlled hypotension (n=40). 10% Dextrose solution vs. No preoperative carbohydrates was evaluated on Amount of Remifentanil consumed per unit time per patient weight (mcg/kg/min) (p=0.083). Preoperative 10% Dextrose did not significantly reduce intraoperative Remifentanil requirement compared to control (0.21 vs 0.18 mcg/kg/min; p=0.083) in surgeries requiring controlled hypotension.
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