Key result
VersaCross supports safe transseptal puncture during challenging TEER after septal closure, facilitated by MR-induced atrial remodeling.
Why the study?
Transseptal puncture is challenging in patients with previously implanted septal closure devices undergoing transcatheter edge-to-edge repair (TEER).
Case Report (n=1)
Chronic atrial remodeling from severe MR can create feasible transseptal puncture zones for TEER even in patients with prior septal closure devices.
May facilitate safe VersaCross transseptal access in post-closure TEER; hypothesis-generating, should not yet change practice.
BACKGROUND: Transseptal puncture is essential for transcatheter edge-to-edge repair (TEER) but is challenging in patients with previously implanted septal closure devices. CASE SUMMARY: A 79-year-old woman with prior transcatheter closure of both a patent foramen ovale and an atrial septal defect developed severe degenerative mitral regurgitation (MR). Transseptal access was considered difficult due to the 2 closure devices. However, chronic MR caused enlargement of the left atrium and interatrial septum, creating a narrow but feasible puncture zone. Using the VersaCross system, transseptal puncture was achieved, allowing TEER completion. DISCUSSION: Left atrial and septal enlargement from MR can create puncturable spaces despite prior septal closure devices. The VersaCross system enables controlled septal crossing, expanding the feasibility of TEER in anatomically complex patients. TAKE-HOME MESSAGE: Chronic atrial remodeling secondary to severe MR may facilitate transseptal access after septal closure, and the VersaCross system can support safe puncture in challenging TEER cases.
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Sato et al. (2026) conducted a case report in Severe degenerative mitral regurgitation with prior PFO and ASD closure devices (n=1). Transseptal puncture using the VersaCross system for TEER was evaluated on Successful transseptal puncture and TEER completion. Transseptal puncture using the VersaCross system was successfully achieved for transcatheter edge-to-edge repair in a patient with two prior septal closure devices.
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