Answers are grounded in this paper and cite their sources.
Herein, we report a novel hydrogen-bond-assisted radiofluorination strategy for the trifluoromethylation of gem-difluoroalkenes, utilizing NIS as the activator and HFIP as the essential solvent to facilitate key hydrogen-bonding interactions. This method demonstrates broad functional group compatibility, delivers high radiochemical yields, and provides an efficient route to α-iodo-[¹⁸F]trifluoromethylated alkanes. These features position the protocol as a valuable tool for the rapid construction of novel positron emission tomography (PET) tracers.
No takes yet. Share an insight, caveat, or question.
Yuzhang et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: