Key result
Endodontic treatment reduces hs-CRP at 6 months without impacting other inflammatory biomarkers.
Why the study?
Does endodontic treatment reduce levels of inflammatory biomarkers associated with cardiovascular risk in patients with apical periodontitis?
Meta-Analysis
Does endodontic treatment reduce levels of inflammatory biomarkers associated with cardiovascular risk in patients with apical periodontitis?
Endodontic treatment of apical periodontitis may reduce hs-CRP levels at 6 months, though the current evidence is of low certainty and requires confirmation by rigorous clinical trials.
A significant reduction in hs-CRP was observed 6 months after endodontic treatment. However, there was no association between endodontic treatment of teeth with AP and the reduction in the other biomarkers evaluated in this systematic review and meta-analysis. Furthermore, the certainty of evidence was classified as low according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, mainly because of the heterogeneity across primary studies and the lack of adequate control for potential confounding factors such as marginal periodontitis and smoking, which are linked to increased systemic inflammatory burden. Well-designed clinical trials using rigorous control of these factors, standardized methodologies, and longer follow-up periods are needed to confirm these findings.
No takes yet. Share an insight, caveat, or question.
Lyra et al. (2026) conducted a meta-analysis in Apical periodontitis. Endodontic treatment was evaluated on Levels of inflammatory biomarkers associated with cardiovascular risk. Endodontic treatment of teeth with apical periodontitis significantly reduced hs-CRP levels at 6 months, but showed no association with other evaluated inflammatory biomarkers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: