February 2, 2007Circulation469 citations
View Full PaperEpidemiology and Cause-Specific Outcome of Hypertrophic Cardiomyopathy in Children
Structured PICO
What are the outcomes and mortality rates of hypertrophic cardiomyopathy in children based on age of presentation?
P
Population
Children with hypertrophic cardiomyopathy (HCM), including those presenting before 1 year of age and those with idiopathic HCM surviving beyond age 1
O
Outcome
Survival/mortalityhard clinical
In children with idiopathic HCM surviving past 1 year of age, the annual mortality rate is 1%, which is significantly lower than previously reported and comparable to adult populations.
Abstract
In children, HCM is a diverse disorder with outcomes that depend largely on cause and age. Patients presenting before 1 year of age have the broadest spectrum of causes and the poorest outcome. In those children with idiopathic HCM who survive beyond age 1, however, survival is independent of age at diagnosis, with an annual mortality rate (1%) that is much lower than previously reported in children and is not different from has been found in population-based studies in adults.