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Extreme hypertrophy may inform sudden death risk stratification in HCM; leaves open optimal intervention thresholds for asymptomatic youth.
In hypertrophic cardiomyopathy, the magnitude of hypertrophy is directly related to the risk of sudden death and is a strong and independent predictor of prognosis. Young patients with extreme hypertrophy, even those with few or no symptoms, appear to be at substantial long-term risk and deserve consideration for interventions to prevent sudden death. The majority of patients with mild hypertrophy are at low risk and can be reassured regarding their prognosis.
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Spirito et al. (2000) studied this question.
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