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April 25, 2000Circulation

Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease

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Why the study?

Does the assessment of coronary endothelial vasoreactivity predict long-term atherosclerotic disease progression and cardiovascular event rates in patients at risk for coronary heart disease?

Population

Patients at risk for coronary heart disease

Design

Review

Authors

VSVolker SchächingerInterventional / Structural CardiologyMBMartina BrittenInterventional / Structural CardiologyAndreas M. ZeiherAndreas M. ZeiherInterventional Cardiology

Discussion

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Implication

May aid risk stratification in at-risk patients; leaves open whether routine assessment improves outcomes.

Structured PICO

Does the assessment of coronary endothelial vasoreactivity predict long-term atherosclerotic disease progression and cardiovascular event rates in patients at risk for coronary heart disease?

P
Population
Patients at risk for coronary heart disease
I
Intervention
Assessment of coronary endothelial vasoreactivity
O
Outcome
Long-term atherosclerotic disease progression and cardiovascular event rates

Assessment of coronary endothelial vasoreactivity can provide pivotal diagnostic and prognostic information regarding atherosclerotic disease progression and cardiovascular events.

Cite This Study

Schächinger et al. (2000) studied this question.

synapsesocial.com/papers/69eededaa84321e0ae63c5abhttps://doi.org/10.1161/01.cir.101.16.1899
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Also Consider

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  1. 1Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.1998 · 338 citations
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  4. 4Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity.1992 · 457 citations
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