Why the study?
Does intravenous glutathione prevent hyperglycemia-induced increases in circulating ICAM-1 levels in NIDDM patients and healthy controls?
Does intravenous glutathione prevent hyperglycemia-induced increases in circulating ICAM-1 levels in NIDDM patients and healthy controls?
Hyperglycemia acutely increases circulating ICAM-1 levels via oxidative stress, an effect that can be abolished by the antioxidant glutathione, supporting a link between hyperglycemia and atherogenesis.
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Oxidative stress may drive acute endothelial activation in hyperglycemia; leaves open glutathione's therapeutic role in diabetes.
Ceriello et al. (1998) studied this question.