July 12, 1995JAMA
Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study
Why the study?
Does serum total cholesterol level predict long-term coronary heart disease mortality across different cultures?
Population
12,467 men aged 40 through 59 years in 16 cohorts located in seven countries
Comparison
Serum total cholesterol levels vs Lowest cholesterol quartile or lower cholesterol…
Design
Cohort
Follow-up
25 years
Authors
Discussion
Loading...
Member takes
Implication
Supports cholesterol as a CHD risk marker across cultures; extends observational data but leaves causal inference and practice change open.
Structured PICO
Does serum total cholesterol level predict long-term coronary heart disease mortality across different cultures?
P
Population
12,467 men aged 40 through 59 years in 16 cohorts located in seven countries (five European countries, the United States, and Japan)
I
Intervention
Serum total cholesterol levels (measured at baseline and at 5- and 10-year follow-up)
C
Comparator
Lowest cholesterol quartile or lower cholesterol levels
O
Outcome
25-year coronary heart disease (CHD) mortalityhard clinical
Serum total cholesterol is linearly associated with long-term CHD mortality across diverse cultures, though absolute mortality rates at a given cholesterol level vary significantly.
Cite This Study
W. M. Monique Verschuren (1995) studied this question.