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January 1, 2001Japanese Circulation JournalOpen Access

Repeated Thermal Therapy Upregulates Arterial Endothelial Nitric Oxide Synthase Expression in Syrian Golden Hamsters.

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Why the study?

Does repeated thermal therapy upregulate arterial endothelial nitric oxide synthase expression in male Syrian golden hamsters?

Population

Male Syrian golden hamsters

Comparison

Sauna therapy using an experimental far… vs Placed in the sauna system switched off at room…

Design

Preclinical

Follow-up

4 weeks

Authors

YIYoshiyuki IkedaSBSadatoshi BiroYKYasuyuki Kamogawa

Discussion

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Overview

Provides preclinical support for thermal therapy mechanisms; leaves open translation to human cardiovascular outcomes.

Structured PICO

Does repeated thermal therapy upregulate arterial endothelial nitric oxide synthase expression in male Syrian golden hamsters?

P
Population
Male Syrian golden hamsters
I
Intervention
Sauna therapy using an experimental far infrared-ray dry sauna system at 39°C for 15 min followed by 30°C for 20 min daily for 4 weeks
C
Comparator
Placed in the sauna system switched off at room temperature of 24°C for 35 min
O
Outcome
Arterial endothelial nitric oxide synthase (eNOS) expressionsurrogate

Repeated thermal therapy upregulates eNOS expression in the arterial endothelium of Syrian golden hamsters, suggesting a molecular mechanism for the cardiovascular benefits of sauna therapy.

Cite This Study

Ikeda et al. (2001) studied this question.

synapsesocial.com/papers/69eedeea0fb71af24d311609https://doi.org/10.1253/jcj.65.434
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