Why the study?
Does chronic heart failure alter the endothelium-dependent and independent vascular responses in rat hindquarter resistance vessels?
Does chronic heart failure alter the endothelium-dependent and independent vascular responses in rat hindquarter resistance vessels?
Endothelium-mediated dilation in response to acetylcholine is attenuated in chronic heart failure due to depressed stimulated release of nitric oxide, while basal release is preserved.
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May indicate selective endothelial impairment in severe experimental HF; leaves open clinical relevance and human translation.
Drexler et al. (1992) studied this question.