March 7, 2013Circulation ResearchOpen Access

Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

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Population

Cardiac myocytes subjected to ischemic stress

Design

Preclinical

Authors

Discussion

May inform GRK2-targeted cardioprotection strategies; animal data leave open human translation and clinical relevance.

Population

Cardiac myocytes subjected to ischemic stress

Intervention

Evaluation of G Protein-Coupled Receptor Kinase 2 (GRK2) signaling

Outcome

Mechanism of GRK2-mediated cell death

This study identifies a novel mechanism by which GRK2 promotes cardiac myocyte death after ischemic stress via mitochondrial targeting.

Chen et al. (2013) studied this question.

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