July 18, 2008Circulation Research

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

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Why the study?

Does GRK2 ablation in cardiac myocytes prevent heart failure and improve outcomes after myocardial infarction in a mouse model?

Structured PICO

Does GRK2 ablation in cardiac myocytes prevent heart failure and improve outcomes after myocardial infarction in a mouse model?

Population

Mice with cardiac myocyte GRK2 ablation after birth (alphaMHC-Cre x GRK2 fl/fl) or after tamoxifen administration (alphaMHC-MerCreMer x GRK2 fl/fl) subjected to surgical coronary artery ligation (myocardial infarction model).

Intervention

Ablation of G protein-coupled receptor kinase 2 (GRK2) in cardiac myocytes before or 10 days after myocardial infarction.

Outcome

Postinfarction cardiac remodeling, beta-adrenergic receptor responsiveness, survival, and cardiac contractile performance.

Ablation of GRK2 in cardiac myocytes after myocardial infarction improves survival and halts ventricular remodeling, supporting GRK2 inhibition as a potential therapeutic target for heart failure.

Discussion

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Implication

Hypothesis-generating for GRK2 inhibition post-MI; leaves open translation to human heart failure trials.

Cite This Study

Raake et al. (2008) studied this question.

synapsesocial.com/papers/69eedef3a84321e0ae63c60c https://doi.org/10.1161/circresaha.107.168336

Topics

Heart failure HFrEF treatment

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G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Topics

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider