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August 1, 1986European Heart Journal

Variations of normal sinus node function in relation to age: role of autonomic influence

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Why the study?

Does sympathetic and parasympathetic blockade reveal age-related changes in intrinsic sinus node function in patients without sinus node disease?

Population

30 patients, 12-79 years of age, without any clinical, electrocardiographic or electrophysiological evidence…

Comparison

Sympathetic and parasympathetic blockade vs Baseline (before autonomic blockade)

Design

Cross-sectional

Authors

MMMichel De MarneffeCentre hospitalier régional de la CitadellePJP JacobsGhent UniversityRHR. HaardtCentre Hospitalier Universitaire de Saint-Pierre

Discussion

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Overview

Autonomic blockade may unmask age-related intrinsic sinus node slowing; hypothesis-generating for compensatory parasympathetic decline maintaining basal stability.

Structured PICO

Does sympathetic and parasympathetic blockade reveal age-related changes in intrinsic sinus node function in patients without sinus node disease?

P
Population
30 patients, 12-79 years of age, without any clinical, electrocardiographic or electrophysiological evidence of sinus node disease.
I
Intervention
Sympathetic and parasympathetic blockade
C
Comparator
Baseline (before autonomic blockade)
O
Outcome
Electrophysiological measurements of sinus node function (resting heart rate, maximal corrected sinus node recovery time and sinoatrial conduction time)surrogate

Normal basal sinus node function remains stable throughout life because the age-related deterioration of intrinsic sinus node properties is counterbalanced by a progressive decrease in parasympathetic activity.

Cite This Study

Marneffe et al. (1986) studied this question.

synapsesocial.com/papers/69eedf3da84321e0ae63c706https://doi.org/10.1093/oxfordjournals.eurheartj.a062120
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