Population
Isolated rabbit ventricular myocytes
Comparison
Direct application of IP3 or endothelin-1 to… vs Baseline conditions and inhibition with IP3R…
Design
Preclinical
Authors
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Findings in rabbit myocytes warrant no practice change; leaves open IP3R as a therapeutic target in human HF.
In rabbit ventricular myocytes, IP3 receptor-dependent Ca2+ release facilitates excitation-contraction coupling, exerting a positive inotropic effect.
Domeier et al. (2007) studied this question.
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