Why the study?
Does intracoronary isosorbide dinitrate improve coronary patency and dilate infarct-related stenosis in patients with acute myocardial infarction receiving intracoronary streptokinase?
Population
45 consecutive patients presenting in the early stages of acute myocardial infarction
Design
Cohort
Authors
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May enhance patency with streptokinase in AMI; hypothesis-generating and requires randomized confirmation before practice change.
Does intracoronary isosorbide dinitrate improve coronary patency and dilate infarct-related stenosis in patients with acute myocardial infarction receiving intracoronary streptokinase?
Spontaneous intermittent coronary recanalization and reocclusion are frequent in early AMI, and intracoronary isosorbide dinitrate combined with streptokinase may increase stable coronary recanalization.
Hackett et al. (1987) studied this question.
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