Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate.
Why the study?
How does advancing age affect cardiac volumes and function during exercise in healthy human subjects?
Population
61 healthy human subjects, age 25 to 79 years, free of overt or occult coronary disease, participating in…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports preserved exercise cardiac output via compensatory dilatation in healthy aging; hypothesis-generating for disease states and longitudinal studies.
Structured PICO
How does advancing age affect cardiac volumes and function during exercise in healthy human subjects?
P
Population
61 healthy human subjects, age 25 to 79 years, free of overt or occult coronary disease (assessed by history, physical, resting/stress ECG, and stress thallium scintigraphy), participating in the Baltimore Longitudinal Study of Aging.
I
Intervention
Progressive upright bicycle exercise to exhaustion with serial gated blood pool scans
O
Outcome
Effect of age on cardiac output, end-diastolic volume, end-systolic volume, stroke volume, ejection fraction, and heart rate at rest and during vigorous exercise (125 W)surrogate
In healthy individuals, exercise cardiac output is maintained with advancing age because cardiac dilatation and increased stroke volume compensate for an age-related decrease in maximal heart rate.
Cite This Study
Rodeheffer et al. (1984) studied this question.