September 1, 2008Current Opinion in Clinical Nutrition & Metabolic Care
The emerging role of the gut in chronic heart failure
Population
Patients with chronic heart failure
Design
Review
Authors
Discussion
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Implication
Gut barrier dysfunction may worsen HF symptoms via inflammation; leaves open microbiome-targeted interventions as future research targets.
Key Points
- To examine how changes in intestinal mucosal integrity, bacterial adherence, and transport protein function contribute to systemic inflammation and symptom progression in chronic heart failure.
- Reviewed theoretical and clinical evidence regarding gut bacterial adherence and mucosal barrier dysfunction in patients with chronic heart failure.
- Assessed pathways linking intestinal transport protein failure and consecutive local or systemic inflammatory cascades to worsening cardiac status.
- Loss of intestinal mucosal barrier integrity enables abnormal bacterial adherence and promotes consecutive local and systemic inflammation.
- Transport protein dysfunction in the gut lining contributes to worsening clinical symptoms in chronic heart failure, identifying the intestinal barrier as a critical therapeutic target.
Structured PICO
P
Population
Patients with chronic heart failure
This review highlights the emerging pathophysiological role of the intestinal barrier and gut microbiome in chronic heart failure, suggesting a target for future research.
Cite This Study
Sandek et al. (2008) studied this question.