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February 28, 2005Critical Care Medicine

Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis*

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Authors

XZXinsheng ZhuMinistry of Ecology and Environment OBOliver Y. BerneckerBrigham and Women's Hospital NMNaveen S. ManoharHarvard University Press

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Implication

Hypothesis-generating for SR Ca leak-targeted therapy in sepsis; prospective trials required before clinical consideration.

Key Points

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Cite This Study

Zhu et al. (2005) studied this question.

synapsesocial.com/papers/69eee0930fb71af24d311bf8 https://doi.org/10.1097/01.ccm.0000152223.27176.a6

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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4Phosphorylation-dependent Alteration in Myofilament Ca2 + Sensitivity but Normal Mitochondrial Function in Septic Heart2001 · 93 citations