Why the study?
Does JTV519 improve defective channel gating of ryanodine receptors in a canine model of tachycardia-induced heart failure?
Population
Dogs with tachycardia-induced heart failure; isolated sarcoplasmic reticulum from left ventricular muscles
Comparison
JTV519 (a 1,4-benzothiazepine derivative) vs Failing sarcoplasmic reticulum without JTV519 /…
Design
Preclinical
Authors
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Caution against clinical use of JTV519; leaves open RyR stabilization as a therapeutic target in human HF.
Does JTV519 improve defective channel gating of ryanodine receptors in a canine model of tachycardia-induced heart failure?
JTV519 corrects defective ryanodine receptor channel gating and improves calcium release in a canine model of tachycardia-induced heart failure.
Kohno et al. (2003) studied this question.
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