Why the study?
Does local urokinase delivery with the Dispatch catheter improve rapid and complete intracoronary thrombolysis compared to standard thrombolytic techniques?
Does local urokinase delivery with the Dispatch catheter improve rapid and complete intracoronary thrombolysis compared to standard thrombolytic techniques?
Local urokinase delivery via the Dispatch catheter achieves rapid intracoronary thrombolysis with less drug than standard techniques by creating a local drug reservoir.
May support efficient local thrombolysis with less drug; hypothesis-generating and should not yet change practice.
Local urokinase delivery with the Dispatch catheter can result in rapid and complete intracoronary thrombolysis using substantially less drug than standard thrombolytic techniques. Intramural deposition of drug with this technique creates a local reservoir of urokinase that may provide prolonged thrombolytic activity at the infusion site.
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Mitchel et al. (1995) studied this question.
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