Randomized trial assesses cognitive decline linked to perivascular spaces in aging, suggesting vascular impacts on brain function.
Basal ganglia PVS burden independently contributes to worse longitudinal executive function and visuospatial skills independent of other SVD markers, highlighting PVS as an emerging marker of domain-specific cognitive decline in aging. Although causation cannot be established, findings further support PVS as a vascular contributor to deep brain structure damage underlying cognitive decline over time.
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Kohno et al. (2026) studied this question.
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