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This study aimed to characterize molecular mechanisms behind high-altitude cognitive dysfunction in mice.

Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction

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Randomized trial investigates gene pathways linked to cognitive dysfunction in mice, suggesting novel treatment avenues.

This study aimed to characterize molecular mechanisms behind high-altitude cognitive dysfunction in mice.
Mice were divided into control and hypobaric hypoxia groups.
Cognitive function was assessed using novel object recognition and Morris water maze tests.
RNA-Seq was used to analyze gene expression and identify differentially expressed genes.
Exposure to hypobaric hypoxia led to significant cognitive impairment and changes in hippocampal tissue.
A total of 178 differentially expressed genes were identified, along with 8 hub genes associated with the PI3K/AKT pathway.
PI3K/AKT pathway inhibition was confirmed with decreased antioxidant protein levels and increased neuroinflammation.

Xin et al. (2026) studied this question.

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