The Beginning of the Ischemic Penumbra and Lindsay Symon

Hideyuki Kuyama

doi:10.7887/jcns.34.279

January 1, 2025Japanese Journal of NeurosurgeryOpen Access

The Beginning of the Ischemic Penumbra and Lindsay Symon

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Key Points

This work aims to explore the origin of the ischemic penumbra concept and its implications for acute cerebral ischemia.
Historical review of literature from 1981 to 1984 regarding ischemic penumbra.
Analysis of the development of measurement devices for cerebral blood flow and ion analysis.
Examination of baboon models of middle cerebral artery occlusion.
The concept of ischemic penumbra highlights thresholds for reversible and irreversible brain injury.
The advancements in reperfusion therapies were significantly influenced by the understanding of ischemic penumbra.
Symon's contributions have been widely recognized and praised by the scientific community.

Implication

Historical analysis revealing the significance of ischemic penumbra in cerebral ischemia, implying advances in treatment.

Abstract

Ischemic penumbraは, 1981年に英国のSymonらにより提唱された. Penumbraの概念は, 脳虚血において可逆的および不可逆的な血流閾値が存在し, 急性期脳梗塞が変化する過程であることを示すものである. 彼らは, 水素法による脳血流量測定装置, 脳表イオン測定装置などを開発し, 霊長類のbaboonの中大脳動脈閉塞による脳虚血モデルを用い, 脳循環と電気生理学的変化などを検討し, ischemic penumbraを提唱するに至った. その後1984年には, penumbraの意義に対して論争があったが, penumbraの概念は, その後の急性期脳梗塞に対する再灌流療法の発展に大きく貢献した. Symon教授の偉大な業績については, 多くの研究者からたたえられている.

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Cite This Study

Hideyuki Kuyama (2025) studied this question.

synapsesocial.com/papers/69eefc6dfede9185760d37d0 https://doi.org/10.7887/jcns.34.279

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The Beginning of the Ischemic Penumbra and Lindsay Symon

Key Points

Implication

Abstract

Discussion

Cite This Study

The Beginning of the Ischemic Penumbra and Lindsay Symon

Key Points

Implication

Abstract

Discussion

Cite This Study

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