What question did this study set out to answer?

To assess the capabilities, methodological limitations, and clinical utility of functional neuroimaging modalities in identifying salvageable penumbra tissue in acute ischemic stroke.

September 1, 2000Journal of Cerebral Blood Flow & MetabolismOpen Access

Ischemic Penumbra: Evidence From Functional Imaging in Man

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To assess the capabilities, methodological limitations, and clinical utility of functional neuroimaging modalities in identifying salvageable penumbra tissue in acute ischemic stroke.
Evaluated functional imaging techniques—including multitracer PET, perfusion- and diffusion-weighted MRI, SPECT, and perfusion CT—across clinical and experimental stroke settings.
Analyzed clinical trial outcomes measuring tissue salvage and final infarct volume following interventional reperfusion therapies.
Current clinical modalities like CT and MRI often fail to reliably distinguish viable penumbra from irreversible tissue damage within the first few hours following stroke onset.
Perfusion measurements alone yield variable flow thresholds that inadequately reflect tissue viability without precise knowledge of individual temporal progression.
Clinical therapeutic trials demonstrate that thrombolytic therapy successfully reverses critical ischemia and limits final infarct volume, validating the biological concept of the ischemic penumbra.

Authors

WHWolf‐Dieter HeissMax Planck Institute for Metabolism Research

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Implication

Review demonstrates challenges in identifying ischemic penumbra using neuroimaging in acute stroke patients, highlighting the need for advanced metabolic tracers.

Cite This Study

Wolf‐Dieter Heiss (2000) studied this question.

synapsesocial.com/papers/6a18a2c5985da83d5491969e https://doi.org/10.1097/00004647-200009000-00002

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Implication

Review demonstrates challenges in identifying ischemic penumbra using neuroimaging in acute stroke patients, highlighting the need for advanced metabolic tracers.

Ischemic Penumbra: Evidence From Functional Imaging in Man

Key Points

Discussion

Implication

Cite This Study

Ischemic Penumbra: Evidence From Functional Imaging in Man

Key Points

Discussion

Implication

Cite This Study

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