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April 27, 2026Radiotherapy and Oncology0 citationsOpen Access

Safety and efficacy of moderately hypofractionated radiotherapy after radical prostatectomy: A phase II trial

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SSSubaru SawayanagiHYHideomi YamashitaTKTaketo Kawai

Key Points

  • This trial aimed to evaluate the safety and efficacy of a specific radiotherapy regimen after prostate surgery.
  • Conducted a phase II trial with patients receiving 54 Gy in 18 fractions of radiotherapy post-radical prostatectomy.
  • Evaluated acute toxicity levels and quality of life after treatment.
  • Monitored biochemical recurrence-free survival over three years.
  • Acute gastrointestinal toxicity was primarily grade 2 and transient.
  • Three-year biochemical recurrence-free survival reached 66%.
  • Overall quality of life remained largely intact post-treatment.

Abstract

Highlights A phase II trial evaluated 54 Gy in 18 fractions after radical prostatectomy. Moderately hypofractionated radiotherapy showed acceptable acute toxicity. Acute gastrointestinal toxicity was mostly grade 2 and transient. Three-year biochemical recurrence-free survival was 66%. Quality of life was largely maintained after treatment.

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Cite This Study

Sawayanagi et al. (2026) studied this question.

synapsesocial.com/papers/69eefcf4fede9185760d3b5chttps://doi.org/10.1016/j.radonc.2026.111549
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Salvage Radiation Therapy After Radical Prostatectomy: Analysis of Toxicity by Dose-Fractionation in the RADICALS-RT Trial2023 · 34 citations
  2. 2Severe Late Toxicities (Grade 3-5) With 13 Years of Follow-up after Hypofractionated Postprostatectomy Radiotherapy2025 · 8 citations
  3. 3Moderate hypofractionation for salvage radiotherapy (HYPO-SRT) in patients with biochemical recurrence after prostatectomy: A cohort study with meta-analysis2022 · 16 citations
  4. 4Adjuvant radiotherapy versus early salvage radiotherapy plus short-term androgen deprivation therapy in men with localised prostate cancer after radical prostatectomy (GETUG-AFU 17): a randomised, phase 3 trial2020 · 333 citations
  5. 5Hypofractionated Radiation Therapy to the Prostate Bed With Intensity-Modulated Radiation Therapy (IMRT): A Phase 2 Trial2020 · 21 citations