Randomized trial demonstrates efficient synthesis of N-alkyl-2,2-dihaloamides, suggesting a solvent-free method.
N-alkyl-2,2-dihaloamides were efficiently prepared by amino-de-alkoxylation of methyl 2,2-dihalocarboxylates, at room temperature without solvents and promoters. Excellent yields of anilides were obtained after addition of AlCl3.
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FORTI et al. (1995) studied this question.
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